When they analyzed bђњgene chipsbђ "on the screen ...

Washington, the influence of smoking activates the genes and parts of the immune system, causing inflammation, which causes a reduction in the life of emphysema, new research shows. Scientists, including two from the University of Texas MD Anderson Cancer Center, described the track toxic smoke takes through the fabric and how they do their destructive work. BЂњItBЂ ™ s like walking in the act, BЂ "said Dr. Farra Kheradmand, professor of medicine and immunology at BCM and senior author of the report. In his current work, the scientists took cells present in BЂњcrime sceneBЂ "each other, piece by piece to find out what happened when and how. This is a complex story that took more than four years for her, her co-senior study author Dr. David Corrie and members of their laboratories and colleagues in Dan L lasix 200 mg. Duncan Cancer Center at BCM, to unravel, she said. BЂњPreviously, emphysema considered harmful nonspecific response to long-term exposure to tobacco smoke BЂ "she said. BЂњThese studies show for the first time that emphysema is caused by a specific immune response induced by smoke. BЂњIt is a combination of genes little affected by epigenetic factors. BЂ "

epigenetics factors that affect genes expressed after DNA form. Cigarette smoke is an environmental epigenetic factors. BЂњIf you have enough genes affect epigenetic factors that are linked together, it can persuade you to the lung and emphysema. Inflammation, which manages emphysema can also manage the development of cancer tested the hypothesis that we were engaged, BЂ "said Kheradmand. This study showed that cigarette job antigen-presenting cells (cells that control immune response systemBЂ ™ s to antigens), as accomplices in the crime to destroy the lungs, using the specific genes that regulate proteins in their deadly role. To find the cause of tobacco induced emphysema, they studied mice subjected to impact conditions that closely simulated the way people smoke. These animals developed lung disease in three to four months. Some inflammatory cells and genes to prove crucial to the process, she said. When they analyzed BЂњgene chipsBЂ "for screening of pathogenic antigen-presenting cells recovered from the lungs of emphysema, they found osteopontin gene that promotes initiation of the inflammatory cascade, which damages the lungs. Kheradmand added that mice that lacked this gene were resistant to emphysema. The study was published in the journal Science Translational Medicine. .