Research links bisphosphonates to rare, but serious, jaw osteonecrosis - prevention is regarded as the best BЂњcure. BЂ "
drugs you take to prevent and treat osteoporosis may be associated with a rare disease called osteonecrosis of the jaw. The reports first appeared in 2003, when Maxillofacial Surgeons said that people who take these drugs - called bisphosphonates - not healing and after they underwent jaw surgery. As preparations to prevent brittle bones actually cause the jaw to rot? How often does this side effect? You at risk? What if you have? Oral bisphosphonates are widely prescribed for people, or at risk for, osteoporosis disease of fragile bones. They are also used in higher doses to treat some cancers. Cancer patients receiving drugs intravenously to treat cancer that spread to the bone and causes pain. In any case, you look at it, many people are - and to be taken - this medication. According to the American Association of Endodontics, more than 30 million Americans take these drugs in the year to treat cancer, osteoporosis and other bone diseases, including PagetBЂ ™ disease (a condition that causes abnormal bone growth). Oral bisphosphonates include alendronate (fosamaks) ibandronat (Boniva), and ryzedronat (Actonel); intravenous form include pamidronat sodium (Aredia), zolendronic acid (Zometa) and clodronate (Bonefos). When the connection between these drugs and osteonecrosis first noticed it happened primarily among people taking these drugs intravenously to treat cancer. In most cases, after major dental procedures such as tooth extraction, but some occurred spontaneously. Currently, many dentists notice state among people who take these drugs in pill form to prevent osteoporosis. As a result, FDA called on manufacturers of all bisphosphonates, include a warning label about the risk of necrosis of the jaw. In addition, the American Society for Bone and Mineral Research in the process of multidisciplinary, international task force to study the issue. Researchers are unsure why these lasix 240 mg drugs can cause disease, but some argue that while bisphosphonates increase bone density in the short term, they can disrupt the formation of new bone in the long run. This may reduce the ability jawboneBЂ ™ s heal after injury, such as tooth extraction or implant. Just as often it is also unknown. A study conducted in
Current Opinions in Orthopaedics, found that between one and 10 percent of people with cancer who are on IV bisphosphonates therapy developed osteonecrosis of the jaw. The number is much lower in people who take these drugs orally for the treatment of osteoporosis. One thing is known, however: Experts agree that the best way to treat osteonecrosis of the jaw is preventing its occurrence in the first place. In this regard, American Association of Dental recently published a guide to help millions of people who take these drugs reduce the risk of this severe condition. First, any person taking these drugs should discuss the risks with the dentist before the procedure related to the jaw. The guidelines also recommend that you:
practice good oral care, including regular brushing and flossing
If your doctor suspects jaw osteonecrosis, he or she may use x-rays or test for infection. Treatment may include antibiotics, oral rinses and removable mouth apparatus. In some cases minor dental work may be necessary to remove damaged tissue and reduce sharp edges of damaged bone. Surgery usually makes the condition worse. WhatBЂ ™ s more, the cessation of therapy Once this condition has developed a little good, because drugs are metabolized slowly and therefore remain in bone for many years. , Associate Professor of Medicine Duke University School of Medicine, said: "DonBЂ ™ t panic. Osteonecrosis of the jaw is a serious disease, but itBЂ ™ s rare. First of all, in patients with IV bisphosphonates to treat forms of cancer, but the apparent speed of less than one per 100,000 person-years in patients taking alendronate for treating osteoporosis. There are fewer cases of other bisphosphonates, but they have not been around as long as alendronate. "To be on the safe side, get a dental evaluation to make sure there is nothing you need to take care near before treatment bisphosphonates. If you are already taking bisphosphonates, let your dentist know, make sure to get regular dental care, and practice good dental and periodontal health. "I advise every patient in my practice who are on oral or IV bisphosphonates for known risks and benefits of therapy.
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